Steroid Derivatives as Potential Antimicrobial Agents against Staphylococcus aureus Planktonic Cells

Steroid Derivatives as Potential Antimicrobial Agents against Staphylococcus aureus Planktonic Cells

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In this work, the antibacterial activity of deflazacort and several of its synthetic precursors was tested against a panel of bacterial pathogens responsible for most drug-resistant infections including Staphylococcus aureus, Enterococcus spp., Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia My Mom Dad Is Well Trained Funny Cartoon Dog Gift For Dog Lover Personalized Shirt coli, and Enterobacter spp.The derivative of deflazacort, PYED-1 (pregnadiene-11-hydroxy-16α,17α-epoxy-3,20-dione-1) showed the best antibacterial activity in a dose-dependent way.

We focused on the action of PYED-1 against S.aureus cells.PYED-1 exhibited an additive antimicrobial effect with gentamicin and oxacillin against the methicillin-resistant S.

aureus isolate 00717.In addition to its antimicrobial effect, PYED-1 was found to repress the expression of several virulence factors of S.aureus, including toxins encoded by the hla (alpha-haemolysin), hlb (beta-haemolysin), lukE-D (leucotoxins E-D), and sea (staphylococcal enterotoxin A) genes, and cell surface factors (fnbB (fibronectin-binding protein B) and capC (capsule biosynthesis protein C)).

The expression levels of here autolysin isaA (immunodominant staphylococcal antigen) were also increased.